H3ch2c

Figure 6.9. Molecular interactions between erythromycin and 50S (E. coli numbering) with various modifications tested for activity, (a) Erythromycin/50S interactions. Dashed lines indicate possible hydrogen bonds (some of which are salt bridges when suitably reinforced with favorable electrostatic potentials). (b and c) Several modifications tested. Arrows point to permissible modifications; arrows with an X point to non-permissible modifications. Dashed arrow points to a modification that is not permissible unless corresponding changes are made elsewhere.

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