Introduction

Nicotinic acetylcholine (ACh) receptors are responsible for transmission of nerve impulses from motor nerves to muscle fibers (muscle types) and for synaptic transmission in autonomic ganglia (neuronal types). They are also present in the brain, where they are presumed to be responsible for nicotine addiction, although little is known about their normal physiological function there. Nicotinic receptors form cation-selective ion channels. When a pulse of ACh is released at the nerve-muscle synapse, the channels in the postsynaptic membrane of the muscle cell open, and the initial electrochemical driving force is mainly for sodium ions to pass from the extracellular space into the interior of the cell. However, as the membrane depolarizes, the driving force increases for potassium ions to go in the opposite direction. Nicotinic channels (particularly some of the neuronal type) are also permeable to divalent cations, such as calcium.

Nicotinic receptors are the most intensively studied type of neurotransmitter-gated ion channel, and in this review we summarize what is known about their structure and function.

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