O Oh

Gentamicin Cla

(member of 4,6 subclass)

Neomycin B

(member of 4,5 subclass)

Figure 6.3. The structures tf" neomycin B and gentamicin Cla.

h3chn *

Gentamicin Cla

(member of 4,6 subclass)

Neomycin B

(member of 4,5 subclass)

Figure 6.3. The structures tf" neomycin B and gentamicin Cla.

both subclasses bind identically; however, because cf alternate linkages that exist between rings II and III, the remaining portions of the two subclasses take different trajectories. The ultimate consequence of AG binding remains the same; 30S is no longer able to discriminate between cognate and noncognate tRNAs when the tRNA binds to the A-site (57).

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