Summary of Effects of Mutations

Before considering the effect of mutations, it is first necessary to ask how accurately it is possible to distinguish binding from gating. The results of single-channel analysis of the sort

Open

Shut

Open

Shut

Apparent open time (ms)

Apparent shut time j t < tcrit (ms)

Apparent open time (ms)

Apparent shut time j t < tcrit (ms)

e L221F 10 nM ACh

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