Ternary Complex Models

The ternary complex model (TCM) (26,27) describes allosteric interactions between orthosteric and allosteric sites present on a single protein monomer and can also be extended to reflect other two-state interactions involving sites on adjacent proteins and the effect of signaling proteins, e.g., G-proteins on the function of the receptor. As noted by Christopoulos (25), allosteric interactions are reciprocal such that the effects of a ligand A on the binding properties of ligand B also imply an effect on the binding of ligand B on the properties of ligand A. Similarly, because GPCRs alter the conformation of G-proteins to elicit transduc-tional events and an alteration in cell function, changes in G-protein conformation and interactions alter receptor function, and this may be reflected in desensitization.

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