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CHAPTER 11 Perspectives and Possibilities in Biomaterials Science

BUDDY D. RATNER 465

APPENDIX Properties of Biological Fluids

STEVEN M. SLACK 469

Index 473

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Contributors

Numbers in parentheses indicate the pages on which the authors' contributions begin.

Harold Alexander (94) Department of Bioengineering, Hospital for Joint Diseases Orthopaedic Institute, New York, New York 10003

James M. Anderson (165, 451) Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106

Brian Bevaequa (420) Case Western Reserve University School of Medicine and Anesthesia Service, Veterans Affairs Medical Center, Cleveland, Ohio 44106 Stanley A. Brown (457) Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Technology, Division of Mechanics and Materials Science, Rockville, Maryland 20852 John B. Brunski (37) Department of Biomedical Engineering,

Rensselaer Polytechnic Institute, Troy, New York 12180 John F. Burke (360) Massachusetts General Hospital, Harvard

Medical School, Boston, Massachusetts 02114 Francis W. Cooke (11) Orthopaedic Research Institute, Wichita, Kansas 67214 Stuart L. Cooper (50) College of Engineering, University of

Delaware, Newark, Delaware 19716 Arthur J. Coury (243) Focal, Inc., Lexington, Massachusetts 02173

A. Norman Cranin (426) Department of Dental and Oral Surgery, Brookdale University Hospital and Medical Center, The Dental Implant Group, Brooklyn, New York 11212

Paul Didisheim (283) Bioengineering Research Group, Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892

Dennis Goupil (356) Datascope Corporation, Fairfield, New Jersey 07004

Linda M. Graham (420) Division of Vascular Surgery, Case Western Reserve University School of Medicine and Vascular Surgery Section, Veterans Affairs Medical Center, Cleveland, Ohio 44106

Anthony G, Gristina (205) Medical Sciences Research Institute, an affiliate of George Mason University, Herndon, Virginia 22070

Stephen R, Hanson (193, 228) Division of Hematology-Oncology, Emory University School of Medicine, Atlanta, Georgia 30322

Laurence A. Harker (193) Division of Hematology—Oncology, Emory University School of Medicine, Atlanta, Georgia 30322

Jorge Heller (346) Advanced Polymer Systems Research Institute, Redwood City, California 94063

Larry L. Hench (73) Department of Materials Science and Engineering, University of Florida, Gainesville, Florida 32611

Robert W. Hergenrother (50) Target Therapeutics, Inc., Free-mont, California 94537

Allan S. Hoffman (37, 105, 124, 443) Center for Bioengineering and Department of Chemical Engineering, University of Washington, Seattle, Washington 98195

Thomas A. Horbett (133) Center for Bioengineering and Department of Chemical Engineering, University of Washington, Seattle, Washington 98195

Richard J. Johnson (173) Baxter Healthcare Corporation, Round Lake, Illinois 60073

Jeffrey B. Kane (360) Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114

J. Lawrence Katz (335) Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106

Michael Klein (426) Department ot Dental and Oral Surgery, Brookdale University Hospital and Medical Center, The Dental Implant Group, Brooklyn, New York 11212

Joachim Kohn (64) Department of Chemistry, Wright and Rieman Laboratories, Rutgers University, Piscatawav, New Jersey 08855

John B. Kowalski (415) Johnson & Johnson, Sterilization Science & Technology, New Brunswick, New Jersey 08906

Peggy A. Lalor (220) Howmedica, Inc., Rutherford, New Jersey 07070

Robert Langer (64) Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Jack E. Lemons (11, 283, 308, 457) Departments of Biomaterials and Surgery, School of Dentistry and Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294

Robert J. Levy (272; Department of Pediatrics, and Communicable Diseases and Pharmaceutics, University of Michigan, Ann Arbor, Michigan 48109

Paul S. Malchesky (400) International Center for Artificial Organs and Transplantation, Cleveland, Ohio 44106

Nancy B. Mateo (461) Statprobe, Inc., Ann Arbor, Michigan 48108

Carl R. McMillin (267) AcroMed Corporation, Cleveland, Ohio 44 115

Katharine Merritt (188) Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Technology, Division of Life Sciences, Gaithersberg, Maryland 20878

Robert F. Morrisscv (415) Johnson 8i Johnson, Sterilization Science & Technology, New Brunswick, New Jersey 08906

Kevin D. Murray (389) Department of Cardiothoracic Surgery, Washington University, St. Louis, Missouri 63110

Paul T. Naylor (205) Tennessee Orthopedic Clinic, Inc., Knox-ville, Tennessee 37922

Steven M. Niemi (238) Genzyme Transgenics Corporation, Framingham, Massachusetts 01701

Sharon J. Northup (215 ) Baxter Healthcare Corporation, Baxter Technology Park, Round Lake, Illinois 60073

Stephen A. Obstbaum (435) New York University School of Medicine, and Department of Ophthalmology, Lenox Hill Hospital, New York, New York 10016

Don B. Olsen (389) Artificial Heart Research Laboratory and Institute for Biomedical Engineering and Division of Artificial Organs, University of Utah, Salt Lake City, Utah 84103

YashwantPathak (272) South Dakota State University, College of Pharmacy, Brookings, South Dakota 57007

Nikolaos A. Peppas (60) Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907

Buddy D. Ratner (1, 21, 105, 133, 215, 228, 243, 445, 465) Center for Bioengineering and Department of Chemical Engineering, University of Washington, Seattle, Washington

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