Acute Hemorrhagic Leukoencephalitis

Acute hemorrhagic leukoencephalitis or Hurst's disease usually develops after a nonspecific upper respiratory infection. The onset is acute, the course fulminant, and the mortality high. Mental changes, focal neurologic deficits, and seizures are common.

Grossly, the brain is swollen and congested, and the white matter displays multiple confluent petechial hemorrhages. Characteristic histological features are fibri-noid necrosis of the arterioles and capillaries, ring- and ball-shaped petechial hemorrhages, and perivascular infiltrations with neutrophils, lymphocytes, and macrophages (Fig. 8.17).

0 0

Post a comment