Adult Adrenomyeloneuropathy

Adult adrenomyeloneuropathy presents with a slowly progressive spastic paraparesis and peripheral neuropathy. It may be associated with cerebral ALD. Demyelin-ation is prominent in the spinal cord, particularly in the posterior columns and pyramidal tracts, but lympho-cytic infiltrations are rare or absent.

Adrenal insufficiency is variably present. Usually it is severe in AMN, in which the testes are also involved. The atrophic adrenal cortex contains ballooned eosino-philic cells, and some contain ultrastructural lamellar inclusions. Similar inclusions are found in the Leydig cells of the testes.

Dietary therapy with Lorenzo's oil is aimed at reducing the rate of synthesis of saturated VLCFAs. The therapy does not seem to be effective in reversing or halting the neurologic symptoms, but it may prevent their development in asymptomatic patients with Addison disease.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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