Ammons Horn Sclerosis in Temporal Lobe Epilepsy

Ammon's horn sclerosis has been identified in a significant number of surgically resected mesio-temporal lobes from patients with a history of intractable or drug-resistant complex partial seizures. Some patients also suffered from generalized tonic-clonic seizures (Fig. 3.13).

A causal relationship between Ammon's horn sclerosis and temporal lobe seizures has often been raised. Ammon's horn sclerosis may develop in a variety of clinical conditions complicated by severe hypoxia: birth injuries, febrile seizures, and vascular, infectious, and

FIGURE 3.13

Ammon's horn sclerosis in temporal lobe epilepsy (cresyl violet stain). Surgically resected right temporal lobe specimen from a 28-year-old woman. At age 11 years, she had a few generalized tonic-clonic seizures. Temporal lobe seizures began at age 23 years.

FIGURE 3.13

Ammon's horn sclerosis in temporal lobe epilepsy (cresyl violet stain). Surgically resected right temporal lobe specimen from a 28-year-old woman. At age 11 years, she had a few generalized tonic-clonic seizures. Temporal lobe seizures began at age 23 years.

traumatic injuries. It is conceivable that Ammon's horn sclerosis, when acquired early in life, may, in time, become epileptogenic, capable of triggering complex partial seizures.

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