Ammons Horn Sclerosis

Grossly, the Ammon's horn is atrophic, gray, and firm, and the adjacent temporal horn is variably dilated. His-tologically, severe or total loss of pyramidal neurons and astrocytic gliosis are present in CA1 zone (Sommer's sector). The lesion may extend beyond the Sommer's sector to involve the entire Ammon's horn (hippocampal sclerosis) and also may extend into the parahippocam-pal regions and amygdala (mesial temporal sclerosis) (Fig. 3.11).

FIGURE 3.12

Cerebellar cortical lobular atrophy in a child with intractable tonic-clonic seizures. Loss of Purkinje cells and granule cells. The cortex is outlined by a prominent Bergmann astrocytic layer (cresyl violet).

FIGURE 3.12

Cerebellar cortical lobular atrophy in a child with intractable tonic-clonic seizures. Loss of Purkinje cells and granule cells. The cortex is outlined by a prominent Bergmann astrocytic layer (cresyl violet).

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