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1. The bacteria that most commonly cause acute purulent meningitis in neonates are:

A. Haemophilus influenzae

B. Escherichia coli

C. Neisseria meningitides

D. All of these

E. None of these

2. Haemophilus influenzae meningitis is often complicated by:

A. Epidural abscess

B. Subdural empyema

C. Subdural hygroma

D. Myocarditis

E. Multiple granulomas


3. Meningococcus meningitis can be complicated by:

A. Skin petechiae

B. Adrenal hemorrhage

C. Disseminated intravascular coagulopathy

D. All of these

E. None of these

4. All of the following concerning tuberculous meningitis are correct except:

A. The exudate is confined to the basal subarachnoid space.

B. Tuberculous granulomas contain coagulative necrosis.

C. The granulomas contain epithelioid cells and lymphocytes.

D. The granulomas contain Langhans giant cells.

E. The glucose level in CSF is low.

5. All of the following concerning general paresis are incorrect except:

A. It is caused by gram positive bacilli.

B. It presents with weakness of extremities.

C. It is caused by Treponema pallidum.

D. It complicates head trauma.

E. Neurons display cytoplasmic inclusions.

6. Fungi are best revealed in paraffin sections using:

A. Masson trichrome stain

B. Grocott methenamine silver stain

C. Phosphotungstic acid hematoxylin (PTAH)

D. Von Kossa stain

E. Congo red stain

7. All of the following concerning cerebral cryp-tococcosis are correct except:

A. It can occur in HIV-infected individuals.

B. The fungi invade small blood vessels.

C. The infection spreads via the bloodstream from a pulmonary infection.

D. The fungi are surrounded by a mucopolysaccharide capsule.

E. The infection manifests as a meningitis.

8. Aspergillosis is characterized by all of the following except:

A. The heart often is involved.

B. The blood vessels show necrotizing vasculitis.

C. The fungi appear as yeasts measuring 2 to 8 microns.

D. Cerebral aspergillosis manifests as granulomas.

E. Cerebral aspergillosis manifests as septic hemorrhagic necroses.

9. Histopathologic changes characteristic of herpes simplex type 1 encephalitis include all of the following except:

A. Hemorrhages in the cerebral cortex

B. Multifocal demyelinations in the white matter

C. Necrosis in the cerebral cortex

D. Eosinophilic cytoplasmic inclusions in the neurons

E. Pathology in the basal-mesial aspects of the frontotemporal lobes

10. Cytomegalovirus encephalitis is characterized by all of the following except:

A. It has a predilection for the walls of the ventricles.

B. The glial cells display cytoplasmic inclusions.

C. The glial cells display nuclear inclusions.

D. It is prevalent among immunosuppressed individuals.

E. CT scan displays massive calcifications in the cerebral and cerebellar cortex.

11. The histology of HIV-encephalitis is characterized by:

A. Microglial nodules containing multinucleated giant cells

B. Cytoplasmic eosinophilic inclusions

C. Periventricular demyelination

D. All of these

E. None of these

12. Neurologic complications of AIDS in children are:

A. Microcephaly

B. Seizures

C. Mineral deposits in the basal ganglia on CT scan

D. All of these

E. None of these

13. A fulminant parasitic hemorrhagic encephalitis acquired by swimming in fresh water is caused by:

A. Entamoeba histolytica

B. Schistosoma species

C. Naegleria fowleri

D. Taenia solium

E. Trichinella spiralis

14. The following apply to neurocysticercosis:

A. It often manifests with seizures.

B. It may cause obstructive hydrocephalus.

C. It is caused by infection with Taenia solium.

D. It is caused by ingesting tapeworm eggs.

(Answers are provided in the Appendix.)


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