Blood Vessels

Vascular supply of the brain and the pathology of arteries are presented in Chapter 4. A few distinct features are mentioned here.

Cerebral arteries differ from systemic arteries by having only one elastic layer.

Capillaries are distinguished by the presence of (a) tight junctions between endothelial cells, (b) basement membrane, and (c) astrocytic foot-plates attached to the adventitia. These three features provide a barrier between the blood and the brain. This blood-brain barrier (BBB) can prevent harmful substances from reaching the nervous parenchyma, but it can also prevent therapeutic agents from crossing to the parenchyma.

Wallerian Degeneration Transsynaptic Atrophy Retrograde Transsynaptic

Atrophy

FIGURE 2.12

Types of degenerations in the central nervous system: schematic drawing.

Wallerian Degeneration Transsynaptic Atrophy Retrograde Transsynaptic

Atrophy

FIGURE 2.12

Types of degenerations in the central nervous system: schematic drawing.

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