Cerebellar Cortical Atrophy

Grossly, the cerebellar folia are atrophic, often in a lobular pattern, the atrophy being more prominent at the depth and walls of the folia than at the crest. His-tologically, the cortex shows Purkinje cell losses and replacement Bergmann astrocytosis. The lobular pattern results from edema that develops during the seizures and compromises the blood flow, first at the depths of sulci (Fig. 3.12).

Scattered laminar and small focal neuronal losses and astrogliosis in the neocortex, amygdala, and thalamus variably occur.

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