Cytoplasmic argyrophilic and tau positive inclusions

These features are characteristic of several neurodegen-erative diseases collectively referred to as tauopathies (see Fig. 2.6).

Viral nuclear inclusions. These inclusions are found in herpes simplex encephalitis, subacute sclerosing panen-cephalitis, and in progressive multifocal leukoencepha-lopathy, in which the astrocytes are transformed into large atypical cells.

Neoplastic transformation. Astrocytes have the capacity to proliferate into a variety of relatively benign or malignant astrocytomas constituting the most common glial tumors.

FIGURE 2.6

Pathology of astrocytes. A. Gemistocytic (reactive) astrocytes display a large eosinophilic glassy cytoplasm with short processes and a peripherally displaced nucleus (HE). B. Fibrillary astrogliosis beneath the pia mater. Fibrous astrocytes showing numerous fine fibrillated processes (Holzer stain). C. Alzheimer's type 2 astrocytes display a large vesicular nucleus with scanty chromatin and a prominent nucleolus (HE). D. Rosenthal fibers in an astrocytoma appear as eosinophilic rod-shaped, homogenous structures (HE). E. Corpora amylacea around blood vessels (HE). F. Argyrophilic astrocytic plaque in cortical basal degeneration (Gallyas). G. Bergmann astrocytes replace degenerated Purkinje cells in cerebellar cortex (HE).

FIGURE 2.6

Pathology of astrocytes. A. Gemistocytic (reactive) astrocytes display a large eosinophilic glassy cytoplasm with short processes and a peripherally displaced nucleus (HE). B. Fibrillary astrogliosis beneath the pia mater. Fibrous astrocytes showing numerous fine fibrillated processes (Holzer stain). C. Alzheimer's type 2 astrocytes display a large vesicular nucleus with scanty chromatin and a prominent nucleolus (HE). D. Rosenthal fibers in an astrocytoma appear as eosinophilic rod-shaped, homogenous structures (HE). E. Corpora amylacea around blood vessels (HE). F. Argyrophilic astrocytic plaque in cortical basal degeneration (Gallyas). G. Bergmann astrocytes replace degenerated Purkinje cells in cerebellar cortex (HE).

All About Alzheimers

All About Alzheimers

The comprehensive new ebook All About Alzheimers puts everything into perspective. Youll gain insight and awareness into the disease. Learn how to maintain the patients emotional health. Discover tactics you can use to deal with constant life changes. Find out how counselors can help, and when they should intervene. Learn safety precautions that can protect you, your family and your loved one. All About Alzheimers will truly empower you.

Get My Free Ebook


Post a comment