Dying Back Degeneration

Degeneration of the axons begins in their distal ends and progresses toward the neurons of their origin. It occurs in systemic degenerative diseases.

FIGURE 2.16

Pseudohypertrophic degeneration of the inferior olivary nuclei in a 45-year-old man with bilateral palatal myoclonus and a large malignant glioma infiltrating the dentate nuclei and the upper midbrain. A. Medulla showing hypertrophy of both inferior olivary nuclei (myelin stain). B. The neurons are enlarged, their cytoplasms vacuolated, and the processes thickened and fragmented (Bodian stain).

FIGURE 2.16

Pseudohypertrophic degeneration of the inferior olivary nuclei in a 45-year-old man with bilateral palatal myoclonus and a large malignant glioma infiltrating the dentate nuclei and the upper midbrain. A. Medulla showing hypertrophy of both inferior olivary nuclei (myelin stain). B. The neurons are enlarged, their cytoplasms vacuolated, and the processes thickened and fragmented (Bodian stain).

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