Embryonal Tumors

Tumors in this group represent the most malignant childhood tumors, corresponding to WHO grade 4. Except for the medulloblastoma, the tumors are rare.

Medulloblastoma, situated in the cerebellum, usually in the midline, accounts for about 20% of all intracranial tumors in young patients. Subtotal resection, the presence of subarachnoid dissemination at the initial evaluation, certain histologic subtypes (large cell/ anaplastic), and genetic alterations (myc17p) make the prognosis worse. Some patients treated with combined radiation and chemotherapy following total or subtotal resection may have a better outcome; survival may reach 5 years.

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