F L

CM?; V *

4 ^

\. Vl^ f ■ '• » *•

rsii

-/.y»

Pick's disease. A. A Pick cell in temporal cortex displays swollen perikaryon and peripherally displaced nucleus (HE). B. Pick bodies appear as argyro-philic globular cytoplasmic inclusions, and (C) are particularly numerous in the dentate gyrus (Bodian stain). D. The Pick body immunoreacts for tau protein (immunostain).

M * ífc '

> %

B

FIGURE 5.15

Corticobasal degeneration. A. Ballooned, achromatic neurons in the hippocampus are devoid of Nissl substance (HE) and (B) stain positively for tau protein (immunostain). C. Astrocytic plaque in cerebral cortex (Gallyas stain).

FIGURE 5.16

Tau-immunopositive fronto-temporal dementia. A 73-year-old man developed partial complex seizures with automatism at age 48 years. Memory decline became evident at age 53 years and steadily progressed. Gradually, he became confused, disoriented, very slow and withdrawn, needing assistance in all his daily activities. A few years prior to his death, he became mute, bedridden, and incontinent. He died 20 years following the onset of memory decline. Family history was not contributory. A. Lateral aspect of the brain shows severe frontal lobe atrophy. B. The cortical ribbon in the frontal lobe is reduced in width, the white matter is severely atrophic, and the anterior horns are enlarged. C. Atrophy of the temporal lobe is moderate.

FIGURE 5.16

Tau-immunopositive fronto-temporal dementia. A 73-year-old man developed partial complex seizures with automatism at age 48 years. Memory decline became evident at age 53 years and steadily progressed. Gradually, he became confused, disoriented, very slow and withdrawn, needing assistance in all his daily activities. A few years prior to his death, he became mute, bedridden, and incontinent. He died 20 years following the onset of memory decline. Family history was not contributory. A. Lateral aspect of the brain shows severe frontal lobe atrophy. B. The cortical ribbon in the frontal lobe is reduced in width, the white matter is severely atrophic, and the anterior horns are enlarged. C. Atrophy of the temporal lobe is moderate.

FIGURE 5.17

Amygdala shows (A) tau-immunopositive neurons and (B) neuritic threads (immunostain).

*

y

i

* •

ft •> % /

«-

* , ' \.

V

- is

1 0

> J-

n

i

*

FIGURE 5.18

Fronto-temporal dementia with ubiquitin-only immunopositive neuronal inclusions. The illness of this 67-year-old man began with memory impairment at age 47. This was followed by progressive deterioration of language and other cognitive functions. He became violent, physically abusive, and exhibited oral tendencies, placing inedible objects in his mouth, drinking detergent, and urine. By the age of 60, he was mute, incontinent, and wheelchair bound. He had positive snout, sucking, and grasp reflexes and cogwheel rigidity in all extremities. He died of an acute cardiorespiratory arrest following a 20-year clinical course. His family history was noncontributory. The brain shows (A) severe circumscribed atrophy of the frontal and (B) anterior temporal and mesio-temporal convolutions.

FIGURE 5.18

Fronto-temporal dementia with ubiquitin-only immunopositive neuronal inclusions. The illness of this 67-year-old man began with memory impairment at age 47. This was followed by progressive deterioration of language and other cognitive functions. He became violent, physically abusive, and exhibited oral tendencies, placing inedible objects in his mouth, drinking detergent, and urine. By the age of 60, he was mute, incontinent, and wheelchair bound. He had positive snout, sucking, and grasp reflexes and cogwheel rigidity in all extremities. He died of an acute cardiorespiratory arrest following a 20-year clinical course. His family history was noncontributory. The brain shows (A) severe circumscribed atrophy of the frontal and (B) anterior temporal and mesio-temporal convolutions.

FIGURE 5.19

A. Dentate gyrus displays neurons with ubiquitin-immunoreactive inclusions.

B. Cortex shows ubiquitin-positive threads (immunostain).

FIGURE 5.19

A. Dentate gyrus displays neurons with ubiquitin-immunoreactive inclusions.

B. Cortex shows ubiquitin-positive threads (immunostain).

0 0

Post a comment