Farbers Disease

Farber's disease of infancy is caused by a deficiency of the enzyme ceramidase, encoded by a gene located on chromosome 8. Ceramide accumulates in the brain, visceral organs, skin, and lymph nodes. Cutaneous nodules, joint pain, hepatosplenomegaly, psychomotor regression, seizures, and a hoarse cry are characteristic clinical manifestations. The pathology is characterized by (a) widespread neuronal storage of PAS-positive ceramide; (b) foamy macrophages in viscera, lymph nodes, and bone marrow; and (c) granulomatous nodules of histio-cytes, lymphocytes, and giant cells in the skin, joints, and various tissues.

Osteoarthritis

Osteoarthritis

Thank you for deciding to learn more about the disorder, Osteoarthritis. Inside these pages, you will learn what it is, who is most at risk for developing it, what causes it, and some treatment plans to help those that do have it feel better. While there is no definitive “cure” for Osteoarthritis, there are ways in which individuals can improve their quality of life and change the discomfort level to one that can be tolerated on a daily basis.

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