General Aspects

Primary brain tumors constitute approximately 2% of all malignancies and 20% of malignancies in children. Brain tumors among adolescents and young adults are the third most common cause of death due to cancer. The survival time in about one-third of patients is poor, averaging 5 years. The prognosis is unfavorable because a significant number of brain tumors grow infiltratively and diffusely, and therefore are not amenable to total resection and are prone to recur, and they are often located in functionally highly specialized or vital regions. Moreover, therapeutic options are limited.

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