Herpesvirus Infections

The family of human herpesviruses encompasses the following important DNA viruses with strong affinity for the nervous tissue:

Varicella zoster virus (VZV)

Cytomegalovirus (CMV)

They are all major causes of sporadic infections.

Herpesviruses, distributed worldwide, may infect the fetus in utero, neonates, and individuals of all ages. The initial infection may be inapparent or mild, producing fever, adenopathy, and nonspecific respiratory symptoms. Characteristically, following an initial infection, HSV-1, HSV-2, and VZV latently reside in the neurons, and CMV and EBV in the hematopoietic cells. Malignancies, febrile illnesses, diabetes, age-related decline of the immune system, and even emotional stress are potential risks for the reactivation of a latent infection. Among immunosuppressed individuals, those with HIV infection are most vulnerable. Once the viruses are reactivated, a variety of neurologic diseases arise in both immunocom-petent and immunocompromised individuals.

0 0

Post a comment