Hypoxic Ischemic Leukoencephalopathy

Hypoxic-ischemic leukoencephalopathy, a rare condition, results from less severe but prolonged hypotension

FIGURE 3.5

Subacute cortical pan-necrosis. A 52-year-old man survived 12 days in a coma following a cardiorespiratory arrest of approximately 28 minutes. A. Transverse section of cerebral hemispheres shows reddish-brown discoloration of the cerebral cortex and softening of the white matter. B. The cerebral cortex is outlined by a darkly stained outer and a faintly stained inner layer. C. The outer layer contains necrotic tissue densely packed with macrophages. A few ischemic neurons are entrapped among macrophages (HE).

FIGURE 3.5

Subacute cortical pan-necrosis. A 52-year-old man survived 12 days in a coma following a cardiorespiratory arrest of approximately 28 minutes. A. Transverse section of cerebral hemispheres shows reddish-brown discoloration of the cerebral cortex and softening of the white matter. B. The cerebral cortex is outlined by a darkly stained outer and a faintly stained inner layer. C. The outer layer contains necrotic tissue densely packed with macrophages. A few ischemic neurons are entrapped among macrophages (HE).

and cerebral hypoperfusion. It is characterized by multiple small areas of demyelination in the cerebral hemispheric white matter (Fig. 3.6). Within these areas, axonal changes vary in severity, macrophages are absent, and astrocytic reaction is insignificant.

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