Infantile Neuroaxonal Dystrophy

Infantile neuroaxonal dystrophy or Seitelberger's disease presents with mental regression, motor deficits, cerebel-lar symptoms, blindness from optic atrophy, seizures, and myoclonic jerks. Death occurs within 3 to 8 years of onset.

Grossly, the brain shows moderately severe generalized atrophy. Histologically, axonal spheroids are distributed widely in the gray matter of the cerebrum and spinal cord, in the peripheral nerves, and in the auto-nomic ganglia. Additional findings are moderate neuronal losses in the cerebral cortex, neuronal and myelin losses in the pallidum, and Purkinje and granule cell degenerations in the cerebellar cortex. The clinical diagnosis is supported by demonstration of axonal spheroids in sural nerve biopsy.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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