Lead Toxicity

Lead toxicity, rare at present, is acquired by exposure to lead-containing paint and dust, and to pica (craving for unnatural food). The toxicity presents with an acute encephalopathy with seizures and signs of raised intra-cranial pressure (ICP). Protein is elevated in the cerebrospinal fluid (CSF). Anemia and basophilic stippling of red blood cells are hematologic abnormalities. Grossly, the brain is edematous. The histology consists of endo-

thelial swelling, leakage of serum into the perivascular space, and occasional petechial hemorrhages.

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