Neurofibromas Grade

These slowly growing benign tumors derive from fibroblasts, Schwann cells, and pericites. Neurofibromas predominate in neurofibromatosis type 1. The two forms of neurofibromas are the cutaneous and the plexiform.

Cutaneous neurofibromas form multiple small nodules and lead occasionally to local elephantiasis. Plexiform neurofibromas affect the somatic and auto-nomic nerves at any site along their course.

Grossly, the tumors enlarge the nerves in a fusiform, cylindrical, or globular fashion. Histologically, they contain bipolar cells arranged in bundles and separated by dense collagenous fibers. Nerve fibers may be detected within the tumors. Neurofibromas may undergo malignant transformation.

0 0

Post a comment