Neuronal Inclusion Bodies in Degenerative Diseases

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Neuronal cytoplasmic inclusion bodies are the distinguishing features of several important neurodegenera-tive diseases. Some are identified in hematoxylin-eosin (HE)-stained sections, others only in silver-stained sections, and still others with immunohistologic stains (see Fig. 2.3). The molecular components of these inclusions are identified using immunohistochemical stains. Some

TABLE 2.3.

Neuronal Cytoplasmic Inclusions in

Degenerative Diseases

Inclusions

Proteins

Neurofibrillary tangle

Tau protein

Pick body

Tau protein

Lewy body

a-Synuclein

Hirano body

Actin

Bunina body

Cystatin C

Skein-like inclusions

TABLE 2.4.

Diseases with Neurofibrillary Tangles

Alzheimer's disease Down's syndrome

Parkinson-Dementia-ALS complex of Guam Progressive supranuclear palsy Postencephalitic parkinsonism Dementia pugilistica Subacute sclerosing panencephalitis Tuberous sclerosis Niemann-Pick disease, type C Gerstmann-Sträussler-Scheinker disease in the cortical neurons of the diffuse Lewy body dementia. They immunoreact for a-synuclein and ubiquitin.

Hirano bodies are rod-shaped or ovoid eosinophilic structures within or adjacent to the pyramidal neurons of the hippocampus in Alzheimer's disease, and they are also found in normal aging. They immunoreact for actin.

Bunina bodies are small, eosinophilic granules in the cytoplasm of motor neurons in amyotrophic lateral sclerosis (ALS). They immunoreact for cystatin C.

Skein-like inclusions in ALS immunoreact for ubiquitin.

Lafora bodies in Lafora disease with myoclonus epilepsy are round, basophilic cytoplasmic inclusions containing polyglucosans that stain strongly with PAS reagent.

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Responses

  • june
    What is neuronal inclusion?
    8 years ago

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