Neuronal Inclusions in Viral Infections

In viral diseases, the inclusions are commonly intranuclear, except that in rabies they occur in the cytoplasm of the Purkinje cells and the pyramidal neurons of the Ammon's horn.

inclusions immunoreact for tau, a microtubule-associated protein, others for a-synuclein, a synaptic protein, and still others for ubiquitin, a stress protein (Table 2.3).

Intranuclear inclusions derived from the proteins of polyglutamate tracts characterize trinucleotide repeat diseases.

Neurofibrillary tangles, a histologic hallmark of Alzheimer's disease, are argyrophilic torch- and basket-shaped or globose filamentous cytoplasmic structures that immunoreact for tau protein. They also are found in normal aging and in a variety of diseases (Table 2.4).

Pick bodies, histologic hallmarks of Pick's disease, are argyrophilic, round, homogenous structures in the swollen perikaryons of cortical and subcortical neurons. They immunoreact for tau protein.

Lewy bodies are eosinophilic, round inclusions in the melanin-containing neurons of the substantia nigra and locus ceruleus in idiopathic Parkinson's disease and

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