Pathology Of Vascular Insults Fetal Period

Vascular insults during the fetal period, from the seventh or eighth week of gestation to birth, can produce a dual pathology; a destructive lesion associated with a malformation. Two major conditions of this period are (a) schizencephaly, often referred to as porencephaly, and (b) hydranencephaly. (See Chapter 13 on malformations.) (Fig. 14.1)

Schizencephaly is a defect in the cerebral wall, which is surrounded by malformed convolutions. It is associated with a vascular insult in the middle cerebral artery territory.

Hydranencephaly, the replacement of the cerebral hemispheres with two membranous cysts, is attributed to a vascular insult in the carotid artery territory.

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