Pathology

The brunt of pathology falls on the cerebellum, peripheral nerves, and spinal cord. The cerebellar pathology is confined to the dentate nuclei, which show extensive neuronal losses. Purkinje cell degeneration is usually mild. The peripheral nerves and sensory nerve roots show axonal and myelin degeneration, and the sensory spinal ganglia show neuronal losses. In the spinal cord, the posterior columns, the dorsal and ventral spinocer-ebellar tracts, the neurons in the Clarke's columns, and the pyramidal tracts are degenerated (Fig. 5.32). Neuronal losses are present in the cuneate and gracile nuclei, and in the cochlear and vestibular nuclei. Degeneration of the optic nerves adds to the pathology.

FIGURE 5.32

Friedreich's ataxia in a 5-year-old boy whose older brother, aged 15 years, suffered from a similar illness. Spinal cord shows degeneration of the posterior columns, pyramidal tracts, and spinocerebellar tracts (Weil stain).

FIGURE 5.32

Friedreich's ataxia in a 5-year-old boy whose older brother, aged 15 years, suffered from a similar illness. Spinal cord shows degeneration of the posterior columns, pyramidal tracts, and spinocerebellar tracts (Weil stain).

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment