Perineurinomas Grade

These rare, benign tumors derive from perineural cells and present in two forms, intraneural and soft-tissue perineurinomas.

The intraneural perineurinoma most often affects the peripheral nerves of the extremities of young adults. Grossly, it appears as a focal enlargement of the nerve. The histology is characterized by onion bulb formation; that is, a concentric arrangement of perineural cells around the myelin and axon. The cells immunoreact for epidermal membrane antigen (EMA) and are negative for S-100 protein.

The soft-tissue perineurinoma occurs in the subcutaneous tissue of the extremities, most often in women. The cells form bundles, interwoven fascicles, and whorls.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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