Rare Pathologic Forms of Dementias

Tangle-only and neuritic plaque-only dementias are variants of AD. The former is characterized by neurofi-brillary tangles and an almost total absence of neuritic plaques, whereas the latter is the opposite: neuritic plaques are present and tangles absent.

Argyrophilic grain dementia is characterized by the presence of argyrophilic and tau- positive, small, spindle-shaped "grains" in the hippocampus, amygdala, and temporoinsular and orbitofrontal regions. The clinical presentation is similar to that of AD.

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