Meningiomas in children are rare, constituting only 3% of pediatric brain tumors; no female predominance is noted. They are more common during the second decade of life but may occur at any age, including in fetuses and infants. In a significant number of children, meningiomas are associated with neurofibromatosis type 2 (NF2), often in the absence of a family history. Ionizing radiation is a potential risk for the development of a menin-
gioma that may occur many years later. Meningiomas in children may reach large sizes, may be cystic, and may be situated within the brain, ventricles, or in the posterior fossa. The various histologic types encountered in adults, including malignant variants, also occur in children. A sclerosing variant, consisting of collagen admixed with spindle cells, is particular to childhood meninginomas.
A correlation between histologic grading and prognosis is unpredictable. Benign meningiomas may recur, whereas malignant grade 2 and 3 meningiomas may have a relatively favorable course. Sporadic and NF2-associated meningiomas showing 1p and 14q deletions have a malignant course.
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