Vitamin B1 Thiamine Deficiency

Thiamine pyrophosphate (TPP) is an important cofactor of the enzyme transketolase, which is involved in glucose metabolism. Deficiency develops in various clinical settings: malnutrition, malabsorption syndromes, chronic gastritis, gastrointestinal malignancies, persistent vomiting, and prolonged intravenous feeding without vitamin supplement. Alcoholics are at particular risk for the disease because of malnutrition; moreover, alcohol interferes with the metabolism, absorption, and storage of thiamine.

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