HCypB (hCyp22.7) hCyp40 and FKBP52

HCypD (hCyp22)





Colorectal cancer Prostate metastasis to bone Lung cancer

Several aggressive metastatic chemotherapy-resistant tumors

Pancreatic cancer Breast cancer

Breast, ovarian, uterine cancers

Prostate cancer Prostate cancer

Breast cancer

Idiopathic myelofibrosis Colorectal cancer

Murine breast cancer

Hepatocellular carcinoma Prostate cancer

Colorectal cancer

Squamous cell carcinoma

Unknown 67

Unknown 68

Unknown 69

Overexpressed almost 70

exclusively in these tumors

Unknown 71

Chaperone for estrogen 72


Apoptosis repressor 73

Unknown 74

Increases androgen receptor 75 transcription

Control ofprogestin and 76

glucocorticosteroid receptor-mediated transcription

Dysregulation of apoptosis 77

Folding of other tumor- 78

associated proteins

Enhances cyclin D1 transcrip- 79 tion and stabilization

Upregulation of b-catenin 80

Unknown - marker of 81

elevated risk of recurrence

Concomitant overexpression 82 of Pinl and b-catenin

Overexpression correlates 83 with cyclin D1 overexpression

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