Preface

The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms act in concert to ensure self-tolerance. During intrathymic development, the nascent T cell repertoire is purged from autoreactive T cells via negative selection, a process also known as recessive tolerance. Ridding of self-reactivity, however, is not complete, as attested by the presence of...

Dendritic Cells Presenting HK ATPase

How autoreactive CD4 T cells become activated to initiate autoimmune disease is an actively investigated area of the pathophysiology of many autoimmune diseases. In the peripheral tissues, dendritic cells DCs sample the environment, acquiring self-antigens from tissue sites, perhaps by the phagocytosis of apoptotic cells Steinman et al. 2003 . These DCs migrate to the draining lymph nodes where they present the antigen in the context of MHC to specific T cells. It has recently been shown that...

References

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