References

The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, Report of the expert committee on the diagnosis and classification of diabetes mellitus, Diabetes Care, 20, 1183, 1997. 2. Eisenbarth, G. S., Type I diabetes mellitus a chronic autoimmune disease, N. Engl. J. Med., 314, 1360, 1986. 3. Atkinson, M. A. and MacLaren, N. K., The pathogenesis of insulin dependent diabetes, N. Engl. J. Med., 331, 1428, 1994. 4. Simone, E. and Eisenbarth, G. S., Chronic autoimmunity of type...

Cell Death

The Role of Poly (ADP-ribose) polymerase Pharmacology and Toxicology Basic and Clinical Aspects Mannfred A. Hollinger, Series Editor University of California, Davis Manual of Immunological Methods, 1999, Pauline Brousseau, Yves Payette, Helen Tryphonas, Barry Blakley, Herman Boermans, Denis Flipo, Michel Fournier CNS Injuries Cellular Responses and Pharmacological Strategies, 1999, Martin Berry and Ann Logan Infectious Diseases in Immunocompromised Hosts, 1998, Vassil St. Georgiev Pharmacology...

Summary And Outlook

The currently available observations from experimental models on the pathogenesis of human type 1 diabetes strongly indicate that inflammatory mediators released during islet infiltration contribute to the destruction of insulin-producing pancreatic beta cells. The radical-induced formation of nuclear DNA strand breaks obviously represents the most prominent primary damage in the beta cell. Recent studies in PARP-deficient animals provided unequivocal evidence for PARP activation and subsequent...