Natural Scleroderma Relief

Natural Scleroderma Relief

Here's a quick look at what this new report covers: Calcium deposits (Calcinosis) noticible on the top layre of skin. How to permanently kill all the pathogenic nano bacteria using an easy to find supermarket product. A simple procedure which will stop the pathogenic bugs from ever returning. The easiest way to rid your body of all its harmful toxins & pollutants. Treating bacterial and fungal problems associated with the gastro-Intestinal tract naturally. A simple detoxification and cleansing agent for the kidneys. Re-build and strengthen your Immune-system. Restore your digestive system to its normal healthy state. Expelling excess free radicals from your body. Removing heavy metals deposits trapped in your body. Dealing with your depression. Re-charging your energy levels. Ease joints. Break down & remove excess calcium from your body without any medical intervention. Stop Acid Reflux problems in days without drugs

Natural Scleroderma Relief Overview

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Other Tests of Tubular Function

Wegener's, vasculitis, rapidly progressive glomerulonephritis Pauci-immune rapidly progressive glomerulonephritis Goodpasture syndrome, renal allograft in Alport syndrome Postinfectious glomerulonephritis Membranoproliferative glomerulonephritis types 1 and 2 Membranoproliferative glomerulonephritis type2 > type 1 Systemic lupus erythematosus Systemic lupus erythematosus Drug-induced systemic lupus erythematosus Scleroderma, CREST syndrome Primary and secondary cryoglobulinemia Monoclonal gammopathies

Causes Of Cancers In

Kojima et al. 66 performed clinicopathological and immunohistochemical analyses on 5 patients with B-cell lymphoma and rheumatic diseases. (2 patients with SLE, 2 with dermatomyositis and 1 with scleroderma). In 3 of the 4 cases examined, Epstein-Barr virus (EBV) encoded small RNAs were seen in a small to large number of the lymphoma cells. The data indicate that, similar to the general population, infection with EBV in SLE patients may be associated with the development of NHL.

Malignancies Occurring During

Case reports suggest that the development of the two diseases is not coincidental and that scleroderma patients have twice the risk of developing malignancies than the general population. Lung and perhaps breast cancers seem to be more frequent in PSS patients. In a Danish series of 344 patients 7 , scleroderma was responsible for a 3-fold increased risk of death (Table 1). Most patients died of PSS-related causes (acute renal crisis, hypertension, lung fibrosis, etc.), but malignancies were also described. Lung cancer was the most frequent cause of death-related malignancies (13 160 deaths). Hematological malignancies were the second most common cause of death in the cancer group (4 cases). The other causes were anecdotal breast and ovarian cancer (3 of each), uterus, ovarian etc. An over-representation of lymphoma has been suggested by others 8 who observed 2 cases of non-Hodgkin's lymphoma in PSS patients. These authors reported that the standardized incidence ratio for all cancers...

Pss And Lung Carcinoma

In 1953, the first report of an association between scleroderma and malignancy 2 described three patients, each with long- standing systemic sclerosis (PSS) and lung involvement. In all three patients carcinoma of the lung was found at necropsy. Further case-reports 3-7 described a similar association between PSS and lung cancer, usually diagnosed in patients known to have had diffused scleroderma involving the lungs for many years prior to the appearance of the malignancy. . The most common type of lung cancer reported in connection with PSS is bronchiolar (alveolar-cell) carcinoma 2-4, 9 (representing less than 4 of all forms of lung cancer). This type of cancer can be found in areas of chronic fibrosis and has been described in association with scarring. It is possible that cell products, including growth factors, might cause sclerodermatous changes 12 , Scleroderma-like skin lesions have been described in some patients with metatstatic secreting carcinoid tumors 13 , and also in...

Pss And Other Solid Tumors

Carcinoma of the esophagus 5 has been described with a slightly increased incidence in PSS patients with esophageal dysmotility. Patients with mainly esophageal disease constitute a unique group, and perhaps, dysphagia with malignancy would suggest scleroderma. Also, older patients with scleroderma should be suspected of having cancer, although the number of such patients is not great. A close temporal relationship between the onset of scleroderma and other tumors has been reported, notably carcinoma of the stomach 15 , colon 16 , rectum 17 , bladder 16 , ovary 6 and cervix 16 ,

Association With Autoimmune Phenomena

The association between HCL and autoimmune disorders such as scleroderma, polymyositis, Raynaud's phenomenon, and various vasculitis, has been described.22 23 Among the vasculopathic syndromes polyarteritis nodosa represents the most frequently associated disorder, with 18 cases reported so far. It has been suggested that a common membrane antigen expressed in leukemia cells and vascular endothelium may lead to a vasculitis by generating cross-reacting antibody.24 Four cases of scleroderma in the setting of HCL have been reported.25-27 It has been postulated that sarcoidosis may be induced directly through hairy

The Prevalence of Neoplasia is Increased in PM and Especially DM

Additional established associations also seem, with rare exceptions, reassuring in terms of cancer risk. These include childhood DM, myositis associated with a defined connective tissue disease such as systemic lupus erythematosus or scleroderma, and myositis occurring as a feature of mixed connective tissue disease 1, 14, 17, 18, 37 10 , Similarly, the presence of antisynthetase ab, which characterizes a subset of myositis frequently featuring with interstitial lung involvement, carries a very low risk of cancer both in literature 10 and in our experience. Unsurprisingly, the same is true for the presence of interstitial pneumonitis. In a series of 63 DM patients, none of the 8 with interstitial pneumonitis had cancer, compared with 18 out of the 55 patients without 41 . Nevertheless, the theoretical risk of pulmonary neoplasia occurring as a long-term complication of pulmonary fibrosis must be kept in mind for patients with connective tissue diseases 17 .

Pss And Breast Cancer

Occasionally, a worsening of the scleroderma was noted when the malignancy recurred, while improvement of skin changes occurred after treatment of the neoplasm 10 . (A similar finding was also noted in connection with bladder carcinoma 10 .) An incidence of breast cancer of up to 17 of all types of neoplasms in PSS is mentioned in several studies. In a number of cases the breast carcinoma was diagnosed after the onset of PSS, whereas, in others the scleroderma developed after the diagnosis and treatment of the malignancy (mastectomy lumpectomy and radio- or chemotherapy). There is no consistent connection between immunosuppressive therapy for scleroderma and the appearance of malignancy. Contrary, scleroderma (localized and systemic) has occasionally developed after radiotherapy for breast cancer. In these cases it is unclear whether the collagen disease may be connected to the malignancy itself, or to the radiation. The explanation suggested for the association of lung carcinoma and...

Autoimmune Diseases

Donors as has been shown for uranium miners heavily exposed to alpha radiation 34 , The higher frequency in older male blood donors compared to younger men or women (Table 3) may also be explained in part by a higher prevalence of silent tumors (prostate, lung) in older men. Unfortunately, we had no information about the smoking habits of these blood donors (3) in the risk group of uranium miners without detectable tumor at time of serum analysis, the highest frequency of p53 AAb could be found in patients with a further increase of risk scleroderma patients and miners with large silicotic opacities 35, 36 and (4) in the follow-up of the autoimmune response in two miners, signs of epitope spreading could be observed.

Alloimmune Or Autoimmunelike Manifestations Following alloBMT

GVHD is a systemic disease caused by T cells in donor bone marrow attacking antigen-presenting cells and tissues of host origin, often causing acute morbidity and mortality during the first few weeks post-BMT. Chronic GVHD may develop several months after BMT. Therefore, GVHD is in fact a purely iatrogenic autoimmune-like disease that may affect almost every tissue, with skin, gastrointestinal tract and liver being the primary candidates. Indeed, chronic active hepatitis, vasculitis, autoimmune neuropathies and autoimmune thrombocytopenia, anemia and leukopenia are rather frequent complications. Chronic GVHD may also mimic lichen planus in the mucous membranes, ophthalmoxerostomia (Sjogren's sicca syndrome) and focal or systemic progressive sclerosis (scleroderma), chronic active hepatitis and SLE, to name just a few of the clinical syndromes that may result from acute and chronic GVHD. Interestingly, some of the symptoms are alloimmune (e.g., chronic active hepatitis) whereas others,...

Antinuclear Antibodies

(RNP) or anti-SSA Ro antibodies also suggest SLE but are less sensitive. Anti-ssDNA antibodies are very characteristic of drug-induced SLE. Anti-Scl-70 antibodies are highly specific for scleroderma and the CREST (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias) syndrome. Anti-SSB La Ha antibodies are characteristic of Sjogren's syndrome.

The Peripheral Vascular System Multiple Choice

Exam, you note that both legs are swollen, with no skin thickening or ulcerations. Pressing your thumb against his tibia reveals soft edema. Auscultation of his lungs reveals no crackles. His heart sounds are regular, with no murmurs, rubs, or gallops. His abdomen reveals a small liver but no discernable fluid wave. What diagnosis of peripheral causes of edema is most likely the cause of his problem

P53 Autoantibodies and Cancer Speciiicity Diagnosis and Monitoring

The presence of p53AAb is generally indicative of malignancy. Nevertheless, rare exceptions become known. In autoimmune diseases (AID), p53AAb can be detected in patients with systemic lupus erythematosus (SLE) 57, 58 , Sjogren's syndrome and systemic sclerosis (scleroderma) 57 , Additionally, we found seropositive individuals among patients with Graves' disease, Wegener's granulomatosis, and other vasculitis 58 , The role of p53AAb in AID is yet unknown. Furthermore, is there an association between p53AAb generation and p53 protein accumulation in patients with AID Recently, extensive apoptosis was demonstrated in most of the epidermis of cutaneous lupus erythematosus lesional skin showed a marked increase in p53 protein-positive keratinocytes 59 . Skin samples from 44 patients with scleroderma, however, revealed no abnormal expression of p53 59 although Kovacs et al. 57 found a p53AAb-positive patient.

Adverse Effects Of Chemotherapy And Rheumatic Symptoms

A number of antineoplastic agents are known to have adverse effects that might mimic a rheumatic disease. For example, Raynaud's phenomenon is well described in association with cisplatin, vinblastine and bleomycin 10 , and more recently 5-fluorouracil may cause digital ischaemia 11 , Furthermore, bleomycin is also associated with the development of scleroderma 12, 13 . The cutaneous lesions seen in these patients treated with bleomycin are indistinguishable from idiopathic scleroderma where lesional fibroblasts synthesize large amounts of collagen and gly-cosaminoglycan 13 . In the patients reported by Kerr and Spiera 12 , the ANA was positive and they also noted some resolution of symptoms after stopping bleomycin and the addition of corticosteroids. Bleomycin in doses of 400 mgs or more may also result in pulmonary fibrosis, a well recognized feature of scleroderma 14 . The mechanism whereby bleomycin can induce a scleroderma like illness remains unknown but vascular injury is...

Pathogenesis

PSS should not be considered a paraneoplastic syndrome unlike other autoimmune diseases, such as some myositis. However, there is a close relationship between the occurrence of some malignancies and scleroderma. Indeed, lung cancers seem to be associated with lung fibrosis more often than with scleroderma. Although alveolar cell carcinoma is the most frequent cancer complicating lung fibrosis in PSS patients, other lung carcinomas, such as squamous cell carcinoma, have been observed 8 . A hypothesis possibly explaining the occurrence of alveolar cell carcinoma could be the mitogenic effect of growth factors implicated in the genesis of lung fibrosis 17 . The changes in the extracellular matrix could also affect the behavior of normal cells 18 . Abu-Shakra et al. 19 hypothesized that an altered immune response could facilitate the occurrence of malignancies. The patient's age at the time that the cancer developed in PSS could also be a factor, since patients over 50 years old at the...

Clinical Features

Werner syndrome was characterized and first described by Dr. Otto Werner at the Kiel University in his doctoral thesis at the turn of 20th century (15). Two symptoms that drew his attention were bilateral cataracts and scleoderma-like skin. The latter turned out to provide insight into the interaction between WRNp and the Ku complex (see Sec. III.E.), the autoantigen that triggers scleroderma, an autoimmune disorder.

Diagnosis

The earliest signs that are suggestive of a diagnosis include failure to thrive, alopecia, and subcutaneous skin changes suggesting scleroderma. Variable degrees of insulin resistance and inconsistent abnormalities of serum cholesterol and other lipids are found, but there are no demonstrable abnormalities of thyroid, parathyroid, pituitary, or adrenal function. We studied five cases of progeria and found 24-hr growth hormone levels to be normal, but reduced levels of insulinlike growth factor I and markedly increased basal metabolic rates were found, suggesting a profile of bioinactive growth hormone (35).

Nyeso1

Factor, antiphospholipid antibodies, antibodies against various tissues) have been detected in sera of tumor patients (reviewed in 35 ). However, two studies including comparative groups of age-adjusted healthy subjects had shown that the increased incidence of RF, anticardiolipin antibodies, ANA as well as the ANA specificities against DNA, histones, Ro SS-A, La SS-B, Sm and Ul-RNP in sera of tumor patients may well reflect the higher age of these patients rather than be a result of the tumor itself 74,75 , Further studies with larger groups of patients and with the inclusion of other AAb specificities should be done to clarify whether there is any specific relationship between defined AAb and cancer. In CTD the strongest associations to epithelial malignancies are in the group of patients with dermatomyositis, polymyositis and systemic sclerosis (reviewed in 35 see also the chapter Scleroderma and Cancer by L. Guillevin). Furthermore, the results of Boyeldieu et al. 76 , Kuwana 77...