Natural Herpes Zoster Cure and Treatment

Fast Shingles Cure

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Fast Shingles Cure Overview


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Varicella Zoster Virus Infection

Varicella-zoster virus (VZV) infection, acquired through the respiratory route, causes varicella in children and zoster in adults. Varicella (chickenpox) is a benign exan- Varicella-zoster virus persists in the neurons of the spinal ganglia, less often in the ganglia of the trigeminal or the facial cranial nerves. Reactivated viruses may afflict the peripheral and the CNS, the skin and the blood vessels, in both immunocompetent and immuno-suppressed individuals.

Herpes Zoster

Herpes zoster (shingles) results when the viruses pass from the ganglia to the skin along the sensory nerves. It commonly occurs in adults, and the incidence increases in the elderly. Clinically, herpes zoster manifests with erythematous vesicles in the skin, associated with pain and sensory deficits in the dermatomes that correspond to the involved ganglia. Common sites are the thoracic dermatomes, the ophthalmic division of the trigeminal nerve (ophthalmic zoster), and the somatosensory branch of the facial nerve (otic zoster). Notably, painful radicular neuropathy may occur in the absence of cutaneous changes. Postherpetic neuralgia is often a protracted disabling complication with severe pain and paresthesias. The pathology of herpes zoster is a radiculogangli-onitis with mononuclear cell infiltrates. In severe cases, the ganglia are hemorrhagic and necrotic, and the inflammation extends into the spinal cord. Granulomatous angiitis of the large arteries may complicate an...

Contraindications and Side Effects

Dactinomycin is contraindicated in the presence of chicken pox or herpes zoster, wherein administration may result in severe exacerbation, occasionally including death. The drug is extremely corrosive in soft tissues, so extravasation can lead to severe tissue damage (14). To avoid this the drug is usually injected into infusion tubing rather than being injected directly into veins. When combined with radiation therapy, exaggerated skin reactions can occur as can an increase in GI toxicity and bone marrow problems. Secondary tumors can be observed in some cases that can be attributed to the drug. Dactinomycin is carcinogenic and mutagenic in animal studies and malformations in animal fetuses have also been observed. Nausea and vomiting are common along with renal, hepatic, and bone marrow function abnormalities. The usual alopecia, skin eruptions, GI ulcerations, proctitis, anemia, and other blood dyscrasias, esophagitis, anorexia, malaise, fatigue, and fever, for example, are also...

Infectious Vasculitis

A number of bacteria and fungi that infect the nervous system often produce an acute inflammatory, necrotizing, or chronic granulomatous vasculitis of the cerebral blood vessels. Spirochetes may infect the blood vessels Treponema pallidum in neurosyphilis and Borrelia burgdorferi in Lyme disease. HIV-associated vasculitis is prone to cause ischemic episodes in both adults and children. Vasculitis of the large cerebral arteries accounts for the hemiplegia that develops contralaterally to a facial or ocular herpes zoster infection. Post varicella vasculopathy is a potential risk for stroke in children.

Longterm Complications

The initial concern for patients treated with the purine nucleosides was for an increased risk of infection and the development of second malignancies due to the profound long-term suppression of CD4 and CD8 lym-phocytes.27 28 However, a significant increase in infections is not seen in patients who have responded to treatment and have normal neutrophil counts. In our series, during the 7-year median follow-up, only herpes zoster was seen in remission patients.24

Guide To Further Reading

Journal of Medicine 338 1281-1292 Gilden D H et al 2000 Neurological complications of the reactivation of varicella-zoster virus. New England Journal of Medicine 342 635-645 Gubareva L V, Kaiser L, Hayden F G 2000 Influenza virus neuraminidase inhibitors. Lancet 355 827-835

Alemtuzumab Campath1H

Alemtuzumab is a humanized monoclonal antibody directed against the lymphocyte surface antigen CD52, which is abundantly expressed on normal and most malignant T lymphocytes.78 Alemtuzumab is currently the focus of many clinical trials in hematologic malignancies and has been used in the treatment of lymphomas and lymphoid leukemias. A published phase II trial of alemtuzumab in 22 patients with advanced MF SS demonstrated a clinical response in 55 of the cases, with 32 complete remissions, including some SS patients clearing effectively circulating Sezary cells.79 Median response duration was 12 months, and ranged from 5 to 32 months. The compound is associated with significant hematologic toxicity and infectious complications consisting of reactivation of cytomegalovirus, herpes zoster, miliary tuberculosis, and pulmonary aspergillosis.

Maintenance and Management of the System

The next two cases differ significantly from the previous two in terms of family life-stage issues. The previous two cases represented the problems of families in their early forties with very young children in one family and a teenage daughter in the other. The next two cases represent a recently married young couple in which the wife suffered from severe migraine, and an older couple in their late sixties in which the husband had many chronic health problems including herpes zoster, which is a very painful condition.

Mr Friesen A Case of Doing Ones Best

Friesen, a retired senior civil servant, presented with a multitude of pain complaints, the worst of them being his persistent pain from herpes zoster. He also had a long history of emphysema and periodic episodes of clinical depression. The marriage had a checkered history. The couple attributed their marital problems mainly to his long-standing health issues. Previously they had a daughter living with them who suffered from Down syndrome and was entirely dependent on them. The history revealed that the marriage ran into problems soon after their disabled daughter was born. Mrs. Friesen received very little practical or emotional support from her husband in raising the child, who subsequently died in her late teens.

Management in Custody

Staff with shingles should stay off work until the lesions are healed, unless they can be covered. Staff who have had chickenpox are immune (including pregnant women) and are therefore not at risk. If they are nonimmune (usually accepted as those without a history of chicken pox), they should avoid prolonged contact with detainees with shingles. Pregnant nonimmune women should avoid contact altogether. severity of the disease, reduces the duration of viral shedding, hastens lesion healing, and reduces the severity and duration of pain. It also reduces the likelihood of developing postherpetic neuralgia (40). Prompt treatment with Famciclovir (e.g., 500 mg three times a day for 7 days) should be initiated if the onset is 3 d ays or less. It should also be considered after this time if the detainee is over age 50 years. Pregnant detainees with shingles can be reassured that there is minimal risk for both the mother and the unborn child. Expert advice should be given before initiating...

Other Systemic Conditions

Bismuth Discolouration Gingiva

Chronic bismuth intoxication is characterized by gastrointestinal disturbances, nausea, vomiting, and jaundice, as well as by an ulcerative gingivostomatitis, generally with pigmentation and accompanied by a metallic taste and burning sensation of the oral mucosa. Ihe tongue may be sore and inflamed. Urticaria, e.xanthematous eruptions of different types, bullous and purpuric lesions, and herpes zoster-like eruptions and pigmentation of the skin and mucous membranes are among the dermatologie lesions attributed to bismuth intoxication. Acute bismuth intoxication, which is less commonly seen, is accompanied by met hemoglobin format ion, cyanosis, and dyspnea.91 Hismuth pigmentation in the oral cavity usually appears

Hazards Of Life On Immunosuppressive Drugs

Impaired immune responses render the subject more liable to bacterial and viral infections. Treat all infection early and vigorously (using bactericidal drugs where practicable) use human gamma globulin to protect if there is exposure to virus infections, e.g. measles, varicella. For example, patients who have not had chickenpox and are receiving therapeutic (as opposed to replacement) doses of corticosteroid are at risk of severe chickenpox they should receive varicella-zoster immunoglobulin if there has been contact with the disease within the previous 3 months.

Infectious Complications

To assess the prophylactic role of IVIG in preventing serious infections, a prospective, randomized, double-blinded, placebo-controlled, multicenter trial including patients with stable phase MM was conducted.41 Patients were not eligible if they had early, progressive, or terminal MM or received any prophylactic antibiotics within the 2 weeks preceding study entry.41 Eighty-three patients were enrolled and randomized to receive IVIG 0.4 g kg or placebo (0.4 albumin) every 4 weeks for 1 year. Patients were stratified by baseline Ig levels. Severity of infection was prospectively defined major infections included culture positive sepsis or clinical sepsis syndrome without documented organism, meningitis, and pneumonia requiring hos-pitalization. Moderate infections consisted of acute bronchitis, upper respiratory or urinary tract infections, skin cellulitis or abscess, and localized zoster. Serious infections included all those considered major or moderate, whereas infections were...

Defects in Cellular Immunity

Infections associated with impaired cellular immunity such as tuberculosis, cryptococcosis, listeriosis, and herpes zoster have been reported in CLL patients even before intensive therapy was available and before techniques were available to identify specific components of cellular immunity. Prominent among these abnormalities are decreased concentrations of circulating CD4+ lymphocytes, which may occur secondary to the disease process but are a significant consequence of therapy with purine analogs.

Infections in Untreated Patients

Herpesvirus infections, predominantly dermatomal herpes zoster and oral herpes simplex, accounted for about 10 of infections (42,43). Other infections associated with CLL were generally identified from studies of specific infections and included tuberculosis, salmonellosis, cryptococcosis, and, rarely, pneumocystosis and progressive multifocal leukoencephalopathy. All of these infections are associated with impaired cellular immunity, indicating that hypo GG was not the sole deficiency in host defenses in nontreated and minimally treated patients.

Infections Associated With Purine Analog Therapy

The largest amount of information on infectious complications following purine analog therapy has been obtained from CLL patients receiving fludarabine. Early studies focused on the increased frequency of L. monocytogenes and P. carinii infections (47). Subsequently, a variety of infections, most of which are typically associated with defects in cellular immunity were reported, primarily as single case reports or only small series. These include infections caused by Legionella species, atypical Mycobacterium species, Nocardia species, and Cryptococcus neoformans (46). Viral infections have included herpes simplex, herpes zoster, cytomegalovirus, adenoviruses, JC virus, respiratory syncytial virus, and astrovirus (48,49). An association between fludarabine therapy may be spurious in some cases, since only single cases have been reported. The largest review of infections associated with fludarabine included 402 CLL patients who received the drug alone or with prednisone (46). The...

An Older Retired Couple

Friesen, in his late sixties and a retired senior civil servant, had multiple health problems, which included chronic back pain, herpes zoster, and a history of depression. Mr. Friesen was disabled to the point that Mrs. Friesen had taken responsibility for all aspects of their day-to-day life. They had an intellectually challenged daughter who subsequently died. The following analysis will show that on the basis of the MMFF, they were found wanting on virtually all dimensions of the MMFF. Yet, given the circumstances, Mrs. Friesen

Treatment of intercurrent illness

Viral infections contracted during steroid therapy can be overwhelming because the immune response of the body may be largely suppressed. This is particularly relevant to immunosuppressed patients exposed to varicella herpes zoster virus, which may cause fulminant illness they may need passive protection with varicella zoster immunoglobulin, VZIG, as soon as practicable. Continuous use of prednisolone 20 mg day (or the equivalent) is immunosuppressive. But a corticosteroid may sometimes be useful in therapy after the disease has begun (thyroiditis, encephalitis) and there has been time for the immune response to occur. It then acts by suppressing unwanted effects of immune responses and excessive inflammatory reaction. Vomiting requires parenteral administration. In the event of surgery being added to that of adrenal steroid therapy the patient should receive hydrocortisone 100-200 mg i.m. or i.v. with premedication. If there is any sign suggestive that the patient may collapse, e.g....

Antimicrobial Prophylaxis

Herpes simplex infections are painful, interfere with nutrition, and may become superinfected with bacterial pathogens. Hence, patients who receive therapy with purine analogs should be considered for prophylaxis with acyclovir or valcyclovir if they have had previous infection (46). Long-term prophylaxis to prevent herpes zoster infections is probably not necessary since nearly all infection is localized to a few dermatomes.

Biology And The Relationship Between Cancer And Aging

In the same way there is a well-characterized remodeling of immune function with advancing age 12. However, the consequences are not fully established even if it is apparent that healthy older individuals are more susceptible to reactivation of tuberculosis or herpes zoster. A clear change in T-cell function with age can be measured in vitro. There is an accumulation of T cells that have cell surface characteristics of memory cells while na ve T cells decrease. Distinct studies suggest that T cells acting as primitive natural killer cells (NK cells) with phenotype intermediate between T and NK cells increase with ageing. B cell immunity is poorly modified but some data suggest that ageing is associated with reduce level of specific gamma globulin and increased level of polyvalent B cells. The concentration of antibodies specific for foreign antigens declines and can be partially explained by a decrease in the number of specific antibody forming cells and impaired T-lymphocyte help as...

Concluding Remarks

Several bioactive marine nucleosides have been isolated from marine organisms. So far marine sponge has been the best source of these nucleosides. The heterocyclic moiety in bioactive marine nucleoside is either a substituted pyrimidine, purine or pyrrolo 2,3-d pyrimidine moiety. The sugar moiety is either D-arabinose, D-ribose, 2'-deoxyribose, 2 ,3'-didehydro,2',3 -dideoxyribose or a substituted xylose sugar. In mycalesine-A and mycalesine-B the sugar moiety is In the nucleoside isolated from the kidney of the giant clam Tridacna maxima, the hydroxy group at position 5 of D-ribose is substituted with 5'-dimethylarsinyl function. Several of these nucleosides have been synthesized. In some cases the compounds have been synthesized prior to the isolation from marine source. Marine nucleosides display antiviral, anticancer, vasodilator, muscle relaxant, and hypertensive activities. Some of them produced bradycardia, and relax smooth muscles. The biological activity of the arabinosides is...

Clinical Approach

Because of the serious complications associated with neutropenia, preventive measures are critical in cancer patients who are receiving chemotherapy. They should be immunized against Pneumococcus and influenza, but administration of live virus vaccines, such as measles-mumps-rubella or varicella-zoster, is contraindicated. G-CSF. which stimulates the bone marrow to produce neutrophils, is frequently used prophylactically in patients receiving chemotherapy to shorten the duration and depth of neutropenia, thereby reducing the risk of infection. It is sometimes used once a neutropenic patient develops a fever, but its use at that point is controversial. Prophylactic use of oral quinolones to prevent gram-negative infection or antifungal agents to prevent Candida infection may reduce certain types of infection but may select for resistant organisms and is not routinely used. In hospitalized patients with neutropenia, use of reverse isolation offers no benefit (the patient is most often...


I have shown, through a detailed case discussion (Roy, 1990), how a couple's adaptation to the husband's herpes zoster and other medical problems deviated to a significant level from effective family functioning as proposed by the McMaster Model of Family Functioning. Simply stated, the well spouse had to take on an extraordinary amount of responsibility to ensure that the instrumental as well as some of the affective needs were met. The patient, who was quite disabled and unable to do much, still was a source of some moral support to his wife, but they had no social life. The point is that chronic illness, unlike acute illness, brings about permanent changes that demand new and novel ways of dealing with them. In many ways, this new family system may have little similarity with that of the premorbid family.

Delayed toxicity

The delayed toxicity profile of 2-CdA in hairy cell leukemia is dominated by its immunosuppressive effects. CD4+ lymphocyte counts become suppressed, and remain so for prolonged periods, after a single 7-day continuous course. The most common late infection in all series was recurrent dermatomal herpes zoster. The severity, duration, and clinical sequelae of this CD4+ lymphocyte depletion was characterized by Seymour et al. in a cohort of 40 patients with hairy cell leukemia treated with continuous infusion 2-CdA at MD Anderson Cancer Center.18 Prior to therapy, 18 patients had lymphocyte subsets analyzed and the median CD4+ count was 743 L (range, 58-2201 L) with a median CD8+ count of 238 L (range, 75-2342 L). Within 4 months of treatment, 25 patients had nadir lymphocyte subsets analyzed with the median CD4+ count suppressed to 139 L (range, 25-580 L), and CD8+ to 92 L (range, 26-879 L). This suppression was prolonged, with a median time of 40 months until CD4+ counts returned to...

Immunity And Aging

There is a well-characterized deficit in immune function with advancing age, but the consequences are not fully established. It is apparent that otherwise healthy older individuals are more susceptible to reactivation of tuberculosis 3,4 or Herpes zoster 5, and responses to vaccines, such as the commercially available and widely used influenza hemagglutinin, are lower 23-25. However, it has been postulated that other age-associated diseases,

Purine Analogs

Other investigators have studied pentostatin for patients with relapsed CTCL or PTCL with prominent cutaneous manifestations.104 Of the 24 patients evaluable for response, six (25 ) patients had CR and 11 (46 ) patients had PR. Ten of 14 (71 ) patients with SS, four of six (66 ) with tumor stage MF, and three of three with PTCL responded. Although the median response duration of the patients with tumor-stage MF was only 2 months (range 1-2 months) and 3.5 months for SS patients, there were two SS patients with prolonged responses lasting greater than 1 year. One of the three PTCL patients had an ongoing CR at 20 months. The most common side effect observed in these patients who had received a median of three prior therapies (range 1-12) was significant lowering of CD4 counts, and several subsequently developed herpes zoster infection.

Special aspects

In other situations someone may complain of being in pain and yet it may be difficult for the professionals to identify any cause for the pain. Some headaches are of this nature, and phantom pain, usually associated with amputation, is another example (Schoenen et al. 1994 Jensen et al. 1985). In other situations the patient may continue to complain of pain when to all intents and purposes the professionals feel that the original injury or disease has been healed or cured. This is particularly common with lower back pain, when there may be no clinical signs of damage or disease to warrant the complaint, or signs of deterioration in the condition. Some diseases of the nervous system can cause intense or long-lasting pain, and yet the clinical signs of disease or damage may be difficult to identify, for example with trigeminal neuralgia or post-herpetic shingles (e.g. Scadding 1994). Yet in all of these situations the experience of the pain is most real and intense to the sufferer. It...


After chicken pox, the virus lies dormant in the dorsal root or cranial nerve ganglia but may re-emerge and typically involves one dermatome (37). The site of involvement depends on the sensory ganglion initially involved. Shingles is more common in individuals over the age of 50 years, except in the immunocompromised, when attacks can occur at an earlier age. The latter are also more susceptible to secondary attacks and involvement of more than one dermatome. Bilateral zoster is even rarer but is not associated with a higher mortality.


There may be a prodromal period of paraesthesia and burning or shooting pains in the involved segment. This is usually followed by the appearance of a band of vesicles. Rarely, the vesicles fail to appear and only pain is experienced. This is known as zoster sine herpete. In individuals who are immuno- Shingles in pregnancy is usually mild. The fetus is only affected if vire-mia occurs before maternal antibody has had time to cross the placenta.


The most common complication of shingles is postherpetic neuralgia, occurring in approx 10 of cases. It is defined as pain lasting more than 120 days from rash onset (39). It is more frequent in people over 50 years and can lead to depression. It is rare in children, including those who are immunocompromised. Infection of the brain includes encephalitis, involvement of motor neurones leading to ptosis, paralysis of the hand, facial palsy, or contralateral hemiparesis. Involvement of the oculomotor division of the trigeminal ganglion can cause serious eye problems, including corneal scarring.

Protective Factors

Decreased risks of glioma that have been found in association with past history of allergies 32-34 , autoimmune diseases 32 or certain common viral infections 33, 35 may all indicate a role for immunological factors in the etiology of glioma. These results should be treated with caution, however, as they were based on questionnaires in case-control studies without validation from medical records. Moreover, proxy respondents supplied information on a substantial proportion of cases, usually because the subject was too ill to respond or had died. For allergies, the odds ratios in different studies were inversely correlated with the percentage of proxy respondents, indicating possible bias 36 . Two studies, however, that were not susceptible to recall bias also provide support for an immune-related etiology of glioma. A large cohort study in Sweden, involving record linkage between the population-based Twin Registry, Hospital Discharge Registry, and Cancer Registry, found an inverse...

Viral Infections

Herpes zoster is the most common severe viral infection associated with CLL (48). Less than 10 of patients experience cutaneous dissemination, and only a few develop visceral dissemination. About 20 suffer from postherpetic neuralgia, and a few develop polyradiculopathy or meningoencephalitis (55,60). Herpes simplex infections of the circumoral area and oropharynx are more common than herpes zoster but are usually not as severe. A chronic indolent form of orofacial herpes simplex infection has been described in a few patients (61). Slowly or rapidly progressive local or widespread lymphadenitis and, rarely, visceral dissemination may occur (62). Occasional patients may develop persistent or recurrent skin lesions after herpes zoster or simplex infection that are caused by infiltration by CLL cells (63).

Media Activities

The infectious agent responsible for chickenpox, the varicella-zoster virus, sometimes causes shingles in older people, because the virus initially evades the immune system and then hides in the nerves in a latent form. You will explore information on what shingles is, how it occurs, and what can be done to treat the affected patient.

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