Anabolic Agents and Testosterone

The use of anabolic drugs, such as methyltestos-terone, oxandrolone, and stanozolol, has been explored in clinical trials with cachectic AIDS patients. Studies showed that nandrolone decanoate decreases the weight loss associated with cancer and HIV [82-84]. The main side effects were masculinisation, fluid retention, and hepatic toxicity [83, 85-87]. The efficacy of nan-drolone decanoate unknown in geriatric patients. However, Batterham and Garsia studied the effects of nandrolone decanoate and MA in HIV patients with weight loss and concluded that both drugs resulted in an increase in fat-free mass greater than that obtained with dietary counselling alone [82]. Oxandrolone has been studied for treating weight loss in patients with HIV infection, cachectic chronic obstructive pulmonary disease (COPD) patients, and cancer patients with weight loss [35, 88-96]. Earthman et al. found that oxandrolone therapy in HIV infection improves weight, quality of life, and lean body mass, with minimal adverse effects [97].

Testosterone has been used as a treatment for cachexia and weight loss in HIV patients with positive results concerning weight and gain of lean muscle mass, but with unknown clinically meaningful changes in muscle function and disease outcome in HIV-infected men [98-102]. Morley et al. safely administered testosterone to older men with hypogonadism and noted an increase in the upper-arm strength of this population [52,103]. Dolan et al. found that testosterone administration increased muscle strength in low-weight HIV-infected women and suggested that it may be a useful adjunctive therapy to maintain muscle function in this group of patients [104,105].

In elderly men, an additional problem associated with the use of testosterone-like drugs might be an exacerbation of prostate cancer, which would therefore limit its use.

Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

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