Cancer Anorexia

Cancer anorexia is defined as the loss of the desire to eat, and several factors are involved in its pathogenesis. Anorexia and reduced food intake are physiological responses prompted by the growing tumour, and persistent anorexia compromises host defences, which ultimately delays recovery. Anorexia contributes to the development of malnutrition and cachexia, since it reduces the oral intake of calories, thus promoting skeletal-muscle wasting [13].

In the methylcholanthrene-induced sarcoma (MCA)-bearing Fischer rat, anorexia develops with progression of tumour growth, so that a characteristic feeding pattern is observed with the onset of anorexia (Fig. 1,11).A decrease in food intake occurs, first via a decrease in meal number associated with a simultaneous partial compensatory increase in meal size that lasts for approximately 24-48 h. Thereafter, meal size also decreases, and anorexia becomes apparent and profound [30-33], leading ultimately to the rats' demise [32]. The decrease in meal size and the resulting anorexia are mediated by the effects of cy-tokine on the hypothalamus, which in turn influences gastric emptying [34]. The same feeding-pattern changes are obtained in normal rats when inter-leukin (IL)-1, alone or together with tumour necrosis factor (TNF),is peripherally infused [35,36]. This suggests a contributory role of cytokines in the pathogenesis of cancer anorexia. Furthermore,we demonstrated that IL-1a concentrations in CSF are inversely correlated with food intake in anorectic tumour-bearing rats [37], while we and others reported the presence of IL-1 receptors in both the ventromedial nucleus (VMN) and the LHA [7,38] and demonstrated the occurrence of IL-1-receptor mRNA expression in the hypothalamus in tumour-bearing rats [7].

Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

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