Interventions To Reduce Cytokines

Physical training can reduce the plasma levels of proinflammatory cytokines in CHF patients. This immunomodulatory effect may be related to the training-induced improvement in functional status of these patients. Plasma levels of TNF-a, soluble TNF receptors I and II (sTNF-RI and sTNF-RII, respectively), IL-6, and soluble IL-6 receptor (sIL-6R) were measured before and after a 12-week program of physical training by patients with stable CHF and a mean left ventricular ejection fraction of 23%. Physical training produced a significant reduction in plasma levels of the measured cytokines. An increase in VO2max was also seen. Good correlations were found between a training-induced increase in VO2max and a training-induced reduction in the levels of the proinflammatory cytokine TNF-a in patients with CHF. In contrast, no significant difference in circulating cytokines was found with physical training in normal subjects [86].

Testosterone levels decline with aging in both men [87] and women [88]. Testosterone replacement in men increases muscle mass [89-91] and strength [92, 93], and decreases fat mass [90, 94, 95]. Adipocytes are a potent source of cytokines, including TNF-a and leptin. The effect of testosterone on functional status may be mediated by reducing cytokine excess through an effect on adipocytes [96-98].

Recently, megestrol acetate, a potent orexigenic agent, has been shown to produce its effects by decreasing cytokine release [99,100]. This suggests that one approach to preventing functional decline is to use a cytokine inhibitor [101]. A large number of other pharmacological agents have been tried, with varying success, with the aim of lowering excessive cytokines [102].

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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