Age Specific incidence

The overall incidence of non-Hodgkin lymphoma increases steadily with age (Table 9.1 and Fig. 9.1), in contrast to Hodgkin lymphoma, which peaks in early adulthood, declines in incidence with age, and increases again in late adulthood (Fig. 9.1) [1]. During the past quarter century in the United States, the incidence of non-Hodgkin lymphoma has increased in each age group through to age 30 years (Table 9.1). In 20- to 29-year-olds, the increase was dramatic, averaging 4-19% per year over 25 years. Most of the increase was in the non-Burkitt, non-Hodgkin Lymphoma category II(b), according to the International Classification of Childhood Cancer (ICCC), which was in part due to the human immunodeficiency virus (HIV) epidemic that occurred during the 1980s and early 1990s (Table 9.1). In the 1979-1997 English registry, non-Hodgkin lymphoma represented 7% of all cancers in adolescents, very similar to the corresponding proportion in the United States.

Figure 9.1

Incidence of malignant lymphoma in the United States by age in persons younger than 45 years, according to the International Childhood Cancer Classification (ICCC), United States SEER, 1975-2000

Table 9.1 Incidence of non-Hodgkin lymphoma in persons younger than 30 years of age, United States, 1975-2000. ICCC International Classification of Childhood Cancer, SEER Surveillance, Epidemiology and End Results, na not available

Age at diagnosis (years)

<5

5-9

10-14

15-19

20-24

25-29

United States population, year 2000 census (in millions)

19.176

20.550

20.528

20.220

18.964

19.381

Non-Hodgkin lymphoma, ICCC 11(b)

Average incidence per million, 1975-2000, SEER

3.4

5.4

7.1

11.7

16.5

27.3

Average annual % change in incidence, 1975-2000, SEER

na

0.2%

2.2%

2.3%

3.6%

6.2%

Estimated incidence per million, year 2000, United States

2.8

5.5

8.8

14.3

21.8

39.3

Estimated number of persons diagnosed, year 2000, U.S.

66

110

147

290

413

762

Burkitt and other non-Hodgkin lymphoma, iCCC ii(c), ii(d), and ii(e)

Average incidence per million, 1975-2000, SEER

2.8

3.7

3.9

3.1

3.6

7.5

Average annual % change in incidence, 1975-2000, SEER

na

-1.0%

-0.7%

1.6%

9.8%

18.5%

Estimated incidence per million, year 2000, United States

1.9

3.2

3.6

3.5

5.6

12.5

Estimated number of persons diagnosed, year 2000, U. S.

54

76

81

72

108

243

Figure 9.2

Incidence of non-Hodgkin lymphoma in the United States by histologic type; United States SEER, 1992-2000

Figure 9.3

Incidence of non-Hodgkin lymphoma in the United States by gender; United States SEER, 1975-2000

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