Clinical Presentation

Prolonged symptom intervals between onset and diagnosis are common in brain tumors in adolescents and young adults. The spectrum of tumors and their common locations in adolescent and young adults, together with the implications of functional anatomy, means that symptomatology is governed by: (1) symptoms of raised intracranial pressure due to obstructive hydro-cephalus or large tumor mass with midline shift, and

(2) specific symptoms due to neurological dysfunction of brain regions involved with the tumor, including the primary site of the tumor and areas where metastatic disease exists.

The SEER and CBTRUS databases do not contain anatomical details. However, as a result of the ranked incidence of histological subtypes in this age group (Fig. 10.2), we can predict that midline supratentorial tumors are likely to predominate, followed by posterior fossa tumors due to tailing of childhood tumor pattern distribution, then by meningeal and skull-based tumors, with cortical tumors and spinal cord tumors occurring least frequently.

0 0

Post a comment